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Symbol
Name
ID

Abcb4
ATP-binding cassette, sub-family B member 4
MGI:97569

Phenotype annotations related to liver/biliary system

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Portal hypertension

Hepatomegaly

Cirrhosis

Hepatic fibrosis

Hepatitis

Intrahepatic cholestasis

Abnormal intrahepatic bile duct morphology

Bile duct proliferation

Biliary cirrhosis

Jaundice

Portal fibrosis

Portal inflammation

Hepatocellular carcinoma

Disease(s) Associated with ABCB4

intrahepatic cholestasis of pregnancy 3

primary biliary cholangitis

progressive familial intrahepatic cholestasis 3

Mouse Phenotypes

liver hemorrhage

portal hypertension

hepatic necrosis

focal hepatic necrosis

abnormal bile duct morphology

bile duct proliferation

dilated bile duct

abnormal gallbladder size

enlarged liver

bile duct inflammation

liver inflammation

abnormal hepatobiliary system morphology

gallstones

abnormal liver morphology

abnormal bile canaliculus morphology

abnormal hepatocyte morphology

abnormal portal triad morphology

liver cirrhosis

liver fibrosis

increased hepatocellular carcinoma incidence

abnormal hepatobiliary system physiology

abnormal bile secretion

biliary cirrhosis

cholestasis

intrahepatic cholestasis

abnormal bile composition

Availability

Mouse Genotype

Abcb4^tm1Bor/Abcb4^tm1Bor

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23